Neurobiology of Disease Modulator Effects of Interleukin-1 and Tumor Necrosis Factor- on AMPA-Induced Excitotoxicity in Mouse Organotypic Hippocampal Slice Cultures
نویسندگان
چکیده
Liliana Bernardino,2 Sara Xapelli,2 Ana P. Silva,2 Birthe Jakobsen,1 Frantz R. Poulsen,1 Catarina R. Oliveira,2 Annamaria Vezzani,3 João O. Malva,2 and Jens Zimmer1 1Anatomy and Neurobiology, Institute of Medical Biology, University of Southern Denmark, DK-5000 Odense C, Denmark, 2Center for Neuroscience and Cell Biology, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal, and 3Laboratory of Experimental Neurology, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, 20157 Milano, Italy
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Characterization of spontaneous network-driven synaptic activity in rat hippocampal slice cultures
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متن کاملCharacterization of spontaneous network-driven synaptic activity in rat hippocampal slice cultures
A particular characteristic of the neonatal hippocampus is the presence of spontaneous network-driven oscillatory events, the so-called giant depolarizing potentials (GDPs). GDPs depend on the interplay between GABA and glutamate. Early in development, GABA, acting on GABAA receptors, depolarizes neuronal membranes via a Cl- efflux. Glutamate, via AMPA receptors, generates a positive feedback n...
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